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Breaking News: Shenzhen Cell Valley Secures World's First International INCI Registration for NK Cell-Derived Exosomes, Ushering in a New Era of Standardized Global Application

Date:03-28  Hits:  Belong to:News & Events

Recently, Shenzhen Cell Valley Biopharmaceutical Co., Ltd. has achieved another milestone breakthrough: the company's NK cell-derived exosomes have successfully obtained International Nomenclature of Cosmetic Ingredient (INCI) registration, assigned the name Human Peripheral Blood Derived Natural Killer Cell Exosomes. This marks a critical step forward in the international standardization, regulation, and industrialization of NK cell derivatives (exosomes) for Shenzhen Cell Valley, signifying that the company has secured a significant first-mover advantage within the international nomenclature system for bioactive ingredients.

INCI (International Nomenclature Cosmetic Ingredient) is a pivotal nomenclature system for the identification and labeling of cosmetic ingredients globally, widely utilized in international cosmetic R&D, registration, production, and market circulation. Securing this international INCI designation not only means that Shenzhen Cell Valley's NK cell derivatives (exosomes) now possess a standardized "ID card" within the international cosmetic ingredient system but also lays a solid foundation for their subsequent global application in fields such as functional skincare, medical aesthetic repair, and high-end anti-aging.

As key effector cells in the innate immune system, NK cells play a vital role in immune surveillance, inflammation regulation, and the maintenance of tissue microenvironment homeostasis. NK cell derivatives (exosomes) carry various active informational molecules from their source cells, exhibiting excellent biocompatibility and high application potential. Compared to traditional skincare active ingredients, NK cell derivatives (exosomes) demonstrate more cutting-edge research and translational value in terms of skin microenvironment regulation, barrier repair, anti-inflammatory soothing, and anti-aging, positioning them as a potential representative of next-generation high-end bioactive cosmetic ingredients. Researchers at Shenzhen Cell Valley have discovered that in cases of skin damage, the reparative effect of NK cell exosomes is even stronger than that of exosomes derived from mesenchymal stem cells (Exclusive Cell Valley research data: NK exosomes exhibit superior skin repair potential and could become a future blockbuster tool for skin repair and anti-aging).

The success of this international INCI registration is not only another major achievement for Shenzhen Cell Valley on the road to exosome industrialization but also an important manifestation of the company's continuous efforts to bring core cell and exosome technologies to the international market. Relying on a comprehensive R&D system, standardized production platforms, and industrial translation capabilities, Shenzhen Cell Valley is accelerating the construction of a full-chain technology platform covering cells, exosomes, viral vectors, and innovative delivery systems, continuously promoting the dual implementation of frontier biotechnology in the fields of medical health and consumer health.

Shenzhen Cell Valley stated that in the future, it will continue to deepen technology R&D, efficacy verification, and application expansion around frontier directions such as NK cell derivatives (exosomes). The company will actively promote the international layout and industrial cooperation of related products, striving to build a Chinese bioactive ingredient brand with global influence and injecting more innovative power from China into the global cosmetics and big health industries.


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Shenzhen Cell Valley Biopharmaceutical Co., Ltd. is a leading one-stop comprehensive outsourcing service provider for China’s cell and gene therapy industry. It is also among the first domestic CRO/CDMO enterprises to hold GMP-compliant industrial production capabilities for clinical-grade retroviral vectors. As a key project for the construction of Shenzhen’s public technical service platform for CRO/CDMO, the company has been listed in the city’s newly announced "20+8" strategic emerging industries initiative.
Shenzhen Cell Valley is equipped with the capacity to conduct standardized and industrialized production of GMP-grade cellular products including CAR-T cells. Its core production lines cover a full spectrum of cellular products such as CAR-T, CAR-NK, CAR-M, γδT, TIL and TCR-T. In addition, the company runs production lines for a diverse range of viral vectors (including RVV, LVV and AAV) and non-viral vectors, as well as for cellular raw materials for therapeutic development—such as exosomes, genetically engineered antibodies, cytokines, oncolytic viruses and vaccines.
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